Restylane Defyne Restylane Defyne is an FDA-approved dermal filler that uses a patented hyaluronic acid gel to smooth away the appearance of moderate-to-severe nasolabial folds and marionette lines. These wrinkles often form due to years of exaggerated and repeated movements of the mouth. Restylane Defyne is an excellent solution for patients who want to minimize the appearance of these lines without inhibiting normal mouth movements. How It Works Restylane Defyne is made up of a patented HA/XpresHAn Technology gel that almost immediately corrects deep lines that stretch from the corner of the nose to the corners of the mouth. In addition to smoothing out these deep wrinkles, Restylane Defyne can trigger long-term collagen production for results that last. Restylane Refyne is delivered into key areas around the nose and mouth via a fine-tip needle. Area It Treats Restylane Defyne is FDA-approved to treat the following areas: Nasolabial folds Marionette lines Benefits Most patients will see Restylane Defyne results about a month after treatment. Patients should expect minor swelling, bruising, and pain at the injection site. Results can last between 6 to 12 months. To learn more about Restylane Defyne or to schedule your consultation at Dermatology Associates of Plymouth Meeting, serving the Philadelphia metro area, including The Main Line, Chestnut Hill, Blue Bell, Gwynedd, and Flourtown, please fill out the form on this page or call 610.947.4322.